Dimer/Hexamer Transition Monitoring via in situ DLS

The insulin model

Monitoring the Transition from a dimeric to a hexameric State of Insulin in Presence of Zn²⁺

Autocorrelation and Size Differences indicate the Transition to Hexamers

The dimer/hexamer Transition is a continuous Process, indicated by the Photon Count Rate in the DLS.

Mean hydrodynamic Radius from intermediate occuring Mixtures of Dimers and Hexamers